Our laboratory explores the processes of brain angiogenesis and blood-brain barrier formation by combining genetic approaches and single-cell resolution imaging in zebrafish embryos. Elaborating on the findings permitted by this potent genetic discovery model, we seek to reach a mechanistic understanding of the processes that couple brain and neural development through complementary approaches in cell biology, mouse genetics as well as cell-free biochemical and biophysical technologies. Molecular investigations of protozoan parasites offer an alternate entry point to our study of human brain barriers and immunity.

striking image-eLife second

This mirror-like image illustrates the beautiful stereotypical patterns of the cerebral vasculature in the transparent zebrafish embryos (left) and their dependency on organotypic angiogenic programs (genetically impaired in the embryo on the right).