A brain-specific angiogenic mechanism enabled by tip cell specialization. Schevenels G, Cabochette P, America M, Vandenborne A, De Grande L, Guenther S, He L, Dieu M, Christou B, Vermeersch M, Germano RFV, Perez-Morga D, Renard P, Martin M, Vanlandewijck M, Betsholtz C, Vanhollebeke B. Nature. 2024 Apr 3. doi: 10.1038/s41586-024-07283-6.
An integrated model for Gpr124 function in Wnt7a/b signaling among vertebrates. America M, Bostaille N, Eubelen M, Martin M, Stainier DYR, Vanhollebeke B. Cell Rep. 2022 May 31;39(9):110902. doi: 10.1016/j.celrep.2022.110902.
Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders. Martin M, Vermeiren S, Bostaille N, Eubelen M, Spitzer D, Vermeersch M, Profaci CP, Pozuelo E, Toussay X, Raman-Nair J, Tebabi P, America M, De Groote A, Sanderson LE, Cabochette P, Germano RFV, Torres D, Boutry S, de Kerchove d’Exaerde A, Bellefroid EJ, Phoenix TN, Devraj K, Lacoste B, Daneman R, Liebner S, Vanhollebeke B. Science. 2022 Feb 18;375(6582):eabm4459. doi: 10.1126/science.abm4459.
Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice. Benz F, Wichitnaowarat V, Lehmann M, Germano RF, Mihova D, Macas J, Adams RH, Taketo MM, Plate KH, Guérit S, Vanhollebeke B, Liebner S. Elife. 2019 Apr 1;8:e43818. doi: 10.7554/eLife.43818.
A molecular mechanism for Wnt ligand-specific signaling. Eubelen M, Bostaille N, Cabochette P, Gauquier A, Tebabi P, Dumitru AC, Koehler M, Gut P, Alsteens D, Stainier DYR, Garcia-Pino A, Vanhollebeke B. Science. 2018 Aug 17;361(6403):eaat1178. doi: 10.1126/science.aat1178.
Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling. Hübner K, Cabochette P, Diéguez-Hurtado R, Wiesner C, Wakayama Y, Grassme KS, Hubert M, Guenther S, Belting HG, Affolter M, Adams RH, Vanhollebeke B, Herzog W. Nat Commun. 2018 Nov 19;9(1):4860. doi: 10.1038/s41467-018-07302-x.
Distinct myocardial lineages break atrial symmetry during cardiogenesis in zebrafish. Guerra A, Germano RF, Stone O, Arnaout R, Guenther S, Ahuja S, Uribe V, Vanhollebeke B, Stainier DY, Reischauer S. Elife. 2018 May 15;7:e32833. doi: 10.7554/eLife.32833.
Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis. Vanhollebeke B, Stone OA, Bostaille N, Cho C, Zhou Y, Maquet E, Gauquier A, Cabochette P, Fukuhara S, Mochizuki N, Nathans J, Stainier DY. Elife. 2015 Jun 8;4:e06489. doi: 10.7554/eLife.06489.
Biallelic mutations in nucleoporin NUP88 cause lethal fetal akinesia deformation sequence. Bonnin E, Cabochette P, Filosa A, Jühlen R, Komatsuzaki S, Hezwani M, Dickmanns A, Martinelli V, Vermeersch M, Supply L, Martins N, Pirenne L, Ravenscroft G, Lombard M, Port S, Spillner C, Janssens S, Roets E, Van Dorpe J, Lammens M, Kehlenbach RH, Ficner R, Laing NG, Hoffmann K, Vanhollebeke B*/Fahrenkrog B*. PLoS Genet. 2018 Dec 13;14(12):e1007845. doi: 10.1371/journal.pgen.1007845.
Mechanism of Trypanosoma brucei gambiense resistance to human serum. Uzureau P, Uzureau S, Lecordier L, Fontaine F, Tebabi P, Homblé F, Grélard A, Zhendre V, Nolan DP, Lins L, Crowet JM, Pays A, Felu C, Poelvoorde P, Vanhollebeke B, Moestrup SK, Lyngsø J, Pedersen JS, Mottram JC, Dufourc EJ, Pérez-Morga D, Pays E. Nature. 2013 Sep 19;501(7467):430-4. doi: 10.1038/nature12516.
Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Genovese G, Friedman DJ, Ross MD, Lecordier L, Uzureau P, Freedman BI, Bowden DW, Langefeld CD, Oleksyk TK, Uscinski Knob AL, Bernhardy AJ, Hicks PJ, Nelson GW, Vanhollebeke B, Winkler CA, Kopp JB, Pays E, Pollak MR. Science. 2010 Aug 13;329(5993):841-5. doi: 10.1126/science.1193032.
A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans. Vanhollebeke B, De Muylder G, Nielsen MJ, Pays A, Tebabi P, Dieu M, Raes M, Moestrup SK, Pays E. Science. 2008 May 2;320(5876):677-81. doi: 10.1126/science.1156296.
Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serum. Vanhollebeke B, Nielsen MJ, Watanabe Y, Truc P, Vanhamme L, Nakajima K, Moestrup SK, Pays E. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4118-23. doi: 10.1073/pnas.0609902104.
Human Trypanosoma evansi infection linked to a lack of apolipoprotein L-I. Vanhollebeke B, Truc P, Poelvoorde P, Pays A, Joshi PP, Katti R, Jannin JG, Pays E. N Engl J Med. 2006 Dec 28;355(26):2752-6. doi: 10.1056/NEJMoa063265.
Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor. Baral TN, Magez S, Stijlemans B, Conrath K, Vanhollebeke B, Pays E, Muyldermans S, De Baetselier P. Nat Med. 2006 May;12(5):580-4. doi: 10.1038/nm1395.
Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes. Pérez-Morga D*/Vanhollebeke B*, Paturiaux-Hanocq F, Nolan DP, Lins L, Homblé F, Vanhamme L, Tebabi P, Pays A, Poelvoorde P, Jacquet A, Brasseur R, Pays E. Science. 2005 Jul 15;309(5733):469-72. doi: 10.1126/science.1114566.