An integrated model for Gpr124 function in Wnt7a/b signaling among vertebrates.

America M, Bostaille N, Eubelen M, Martin M, Stainier DYR, Vanhollebeke B. Cell Rep. 2022 May 31;39(9):110902. doi: 10.1016/j.celrep.2022.110902.

Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders.

Martin M, Vermeiren S, Bostaille N, Eubelen M, Spitzer D, Vermeersch M, Profaci CP, Pozuelo E, Toussay X, Raman-Nair J, Tebabi P, America M, De Groote A, Sanderson LE, Cabochette P, Germano RFV, Torres D, Boutry S, de Kerchove d’Exaerde A, Bellefroid EJ, Phoenix TN, Devraj K, Lacoste B, Daneman R, Liebner S, Vanhollebeke B. Science. 2022 Feb 18;375(6582):eabm4459. doi: 10.1126/science.abm4459. Epub 2022 Feb 18.PMID: 35175798

Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice.

Benz F, Wichitnaowarat V, Lehmann M, Germano RF, Mihova D, Macas J, Adams RH, Taketo MM, Plate KH, Guérit S, Vanhollebeke B, Liebner S. Elife. 2019 Apr 1;8:e43818. doi: 10.7554/eLife.43818.PMID: 30932814 

Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling.

Hübner K, Cabochette P, Diéguez-Hurtado R, Wiesner C, Wakayama Y, Grassme KS, Hubert M, Guenther S, Belting HG, Affolter M, Adams RH, Vanhollebeke B, Herzog W. Nat Commun. 2018 Nov 19;9(1):4860. doi: 10.1038/s41467-018-07302-x.PMID: 30451830 

A molecular mechanism for Wnt ligand-specific signaling.

Eubelen M, Bostaille N, Cabochette P, Gauquier A, Tebabi P, Dumitru AC, Koehler M, Gut P, Alsteens D, Stainier DYR, Garcia-Pino A, Vanhollebeke B. Science. 2018 Aug 17;361(6403):eaat1178. doi: 10.1126/science.aat1178. Epub 2018 Jul 19.PMID: 30026314

Distinct myocardial lineages break atrial symmetry during cardiogenesis in zebrafish.

Guerra A, Germano RF, Stone O, Arnaout R, Guenther S, Ahuja S, Uribe V, Vanhollebeke B, Stainier DY, Reischauer S. Elife. 2018 May 15;7:e32833. doi: 10.7554/eLife.32833.PMID: 29762122 

Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis.

Vanhollebeke B, Stone OA, Bostaille N, Cho C, Zhou Y, Maquet E, Gauquier A, Cabochette P, Fukuhara S, Mochizuki N, Nathans J, Stainier DY. Elife. 2015 Jun 8;4:e06489. doi: 10.7554/eLife.06489.PMID: 26051822

Translational profiling through biotinylation of tagged ribosomes in zebrafish.

Housley MP, Reischauer S, Dieu M, Raes M, Stainier DY, Vanhollebeke B. Development. 2014 Oct;141(20):3988-93. doi: 10.1242/dev.111849. Epub 2014 Sep 17.PMID: 25231762 

Biallelic mutations in nucleoporin NUP88 cause lethal fetal akinesia deformation sequence.

Bonnin E, Cabochette P, Filosa A, Jühlen R, Komatsuzaki S, Hezwani M, Dickmanns A, Martinelli V, Vermeersch M, Supply L, Martins N, Pirenne L, Ravenscroft G, Lombard M, Port S, Spillner C, Janssens S, Roets E, Van Dorpe J, Lammens M, Kehlenbach RH, Ficner R, Laing NG, Hoffmann K, Vanhollebeke B, Fahrenkrog B. PLoS Genet. 2018 Dec 13;14(12):e1007845. doi: 10.1371/journal.pgen.1007845. eCollection 2018 Dec.PMID: 30543681 

Defective adgra2 (gpr124) splicing and function in zebrafish ouchless mutants.

Bostaille N, Gauquier A, Stainier DY, Raible DW, Vanhollebeke B. Development. 2017 Jan 1;144(1):8-11. doi: 10.1242/dev.146803. Epub 2016 Dec 15.PMID: 27979884

The molecular arms race between African trypanosomes and humans.

Pays E, Vanhollebeke B, Uzureau P, Lecordier L, Pérez-Morga D. Nat Rev Microbiol. 2014 Aug;12(8):575-84. doi: 10.1038/nrmicro3298. Epub 2014 Jun 30.PMID: 24975321

Mechanism of Trypanosoma brucei gambiense resistance to human serum.

Uzureau P, Uzureau S, Lecordier L, Fontaine F, Tebabi P, Homblé F, Grélard A, Zhendre V, Nolan DP, Lins L, Crowet JM, Pays A, Felu C, Poelvoorde P, Vanhollebeke B, Moestrup SK, Lyngsø J, Pedersen JS, Mottram JC, Dufourc EJ, Pérez-Morga D, Pays E. Nature. 2013 Sep 19;501(7467):430-4. doi: 10.1038/nature12516. Epub 2013 Aug 21.PMID: 23965626

Association of trypanolytic ApoL1 variants with kidney disease in African Americans.

Genovese G, Friedman DJ, Ross MD, Lecordier L, Uzureau P, Freedman BI, Bowden DW, Langefeld CD, Oleksyk TK, Uscinski Knob AL, Bernhardy AJ, Hicks PJ, Nelson GW, Vanhollebeke B, Winkler CA, Kopp JB, Pays E, Pollak MR. Science. 2010 Aug 13;329(5993):841-5. doi: 10.1126/science.1193032. Epub 2010 Jul 15.PMID: 20647424


A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans.

Vanhollebeke B, De Muylder G, Nielsen MJ, Pays A, Tebabi P, Dieu M, Raes M, Moestrup SK, Pays E. Science. 2008 May 2;320(5876):677-81. doi: 10.1126/science.1156296.PMID: 18451305

Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serum.

Vanhollebeke B, Nielsen MJ, Watanabe Y, Truc P, Vanhamme L, Nakajima K, Moestrup SK, Pays E. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4118-23. doi: 10.1073/pnas.0609902104. Epub 2007 Feb 26.PMID: 17360487

Human Trypanosoma evansi infection linked to a lack of apolipoprotein L-I.

Vanhollebeke B, Truc P, Poelvoorde P, Pays A, Joshi PP, Katti R, Jannin JG, Pays E. N Engl J Med. 2006 Dec 28;355(26):2752-6. doi: 10.1056/NEJMoa063265.PMID: 17192540

The trypanolytic factor of human serum.

Pays E, Vanhollebeke B, Vanhamme L, Paturiaux-Hanocq F, Nolan DP, Pérez-Morga D. Nat Rev Microbiol. 2006 Jun;4(6):477-86. doi: 10.1038/nrmicro1428.PMID: 16710327

Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor.

Baral TN, Magez S, Stijlemans B, Conrath K, Vanhollebeke B, Pays E, Muyldermans S, De Baetselier P. Nat Med. 2006 May;12(5):580-4. doi: 10.1038/nm1395. Epub 2006 Apr 9.PMID: 16604085

Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes.

Pérez-Morga D, Vanhollebeke B, Paturiaux-Hanocq F, Nolan DP, Lins L, Homblé F, Vanhamme L, Tebabi P, Pays A, Poelvoorde P, Jacquet A, Brasseur R, Pays E. Science. 2005 Jul 15;309(5733):469-72. doi: 10.1126/science.1114566.PMID: 16020735